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Caring for the Ages
Selected Articles from
April 2003;
Vol. 4, No. 4
Implementing AMDA's Falls & Fall Risk CPG in the Clinical Setting
A Systematic, Evidence-Based Approach to Managing Challenging Behavior in Nursing Homes
Clinical AbstractScan
Pain in the Elderly: Listen to the Patient's Voice
A Daughter's Journal: During a Visit, "the Play's the Thing"
Reducing Medication Errors in Nursing Homes
Elders Urged to "Dance to Your Heart's Content"
Previous Month's Articles
Following Month's Articles

Reducing Medication Errors in Nursing Homes

by Jacqueline Vance, RNC,
AMDA's Director of Clinical Affairs

There are myriad situations that may lead to medication errors. For example, a newly admitted resident arrives from an acute care hospital late in the day with only a transfer summary dictated by an orthopedic surgeon. The attending physician, who is new to the patient, is called to approve the transfer orders. He returns the call after the admitting nurse has left and is given incomplete information about the patient from an agency nurse. It may be that an inadequately trained ward clerk is assigned to transcribe the handwritten admission orders, to be verified by a harried nurse in a hurry to go home. Medications might be delivered to the facility from the pharmacy, but the contents of the delivery bag are not verified.

The more medications a patient is taking, the greater the chance of interactions, and the greater the risk of errors. Medicaid data for one state showed that during a 30-day period, 68% of long-term care patients had received 9 or more prescription drugs, and 32% had received 20 or more prescription drugs.

Although only a small number of medication errors actually cause adverse drug events (ADEs), as many as 50% of ADEs are caused by errors. Their consequences--falls and fractures as well as greatly increased costs (see boxes at right)--can't be ignored.

Major Consequences of ADEs in Nursing Homes
  • Falls and fractures
  • Malnutrition
  • Dehydration
  • Incontinence
  • Delirium
  • Behavior problems

What Causes Prescribing Errors?
Ordering Errors
Wrong dose 63%
Failure to consider drug interaction 22%
Wrong choice 9%
Monitoring Errors
Failure to order monitoring 83%
Delayed response, or failure to respond, to signs and symptoms of drug toxicity or to laboratory evidence of toxicity 41%
Source: Gurwitz et al. Incidence and preventability of Adverse Drug Events in Nursing Homes. American Journal of Medicine 2000;109:87

Estimated Annual Cost of ADEs
  • Average hospital cost: $1,939 to $2,595 per ADE
  • Total additional hospital cost: $1.56 to $4 billion
  • Nursing facilities excess cost due to ADEs: $7.6 billion
  • Total cost in ambulatory setting: $76.6 billion (includes $47.4 billion due to resulting hospital admissions and $14.4 billion due to resulting LTC admissions).

Source: GAO 2000

Strategies for Clinical Process Improvement
  • Implementing clinical systems and processes.
  • Processes to assure timely information transfer from other facilities.
  • Drug information available at nursing stations.
  • Tools to document efficacy and monitoring for ADRs.
  • Systems to report, review, and analyze medication error and ADR reports.
  • Protocols for use of non-pharmacological interventions (sleep protocols, behavioral interventions, pain management modalities etc.).

Types of Errors

The majority of prescribing errors involve lack of assessment, lack of monitoring for efficacy, lack of reassessment for continuous need, lack of monitoring for adverse drug reactions (ADRs), lack of recognition of ADRs, and attributing symptoms of ADRs to other causes (see box at right). Inadequacies in physician education or training in principles of geriatric assessment and pharmacology may lead to such problems.

Physician attitudes can also play a role in prescribing errors. For example, some physicians refuse to consider non-pharmacologic interventions to treat certain conditions. Other physicians may refuse to consider pharmacy consultants' recommendations for medication changes when there may be a high risk of drug interaction with a current medication regime.

In addition, physicians face many pressures while practicing in long-term care--for instance, having to see many patients in one facility while trying to squeeze in emergency calls and a busy office practice. Low reimbursement for nursing home visits despite high demands can be frustrating to many physicians. Coupled with that is the usual burdensome filling out of dozens of forms and progress notes to fulfill documentation requirements. There is also the fear of regulatory consequences and having to deal with conflicting and sometimes unreasonable and poorly understood regulations.

Finally, there is a dearth of general management as well as medication-specific information systems that can facilitate prescribing, administration, and monitoring of medications. When there are no established processes for obtaining patient-specific information from other facilities or practitioners, for proper assessment and cause-finding, or for communication among various practitioners and team members,medication errors are bound to occur.

Ongoing Problem

The response to the problem of medication errors is not new, but a continuation of a response that started years ago. In 1974, nursing facilities became the only health care institutions required to obtain the services of a consultant pharmacist, who was charged with medication regimen reviews that physicians were required to respond to. Because there was continuing evidence of problems, under OBRA '87, additional regulations were developed that attempt to "micro-manage" the process of prescribing. Further regulations were added in the '90s.

The regulations also provided surveyors with an investigative protocol to review the potential for ADRs. Investigators are instructed to ask specific questions, including: Was the risk for ADRs identified? Did the benefit of a drug outweigh the risk? Is the drug in use a valid therapeutic intervention? Was the ADR identified, was it reported, and what was the response?

Physicians and facilities must be prepared to not only answer these questions, but also show documented evidence that supports their answers. According to guidance to surveyors in the State Operations Manual (SOM; Appendix Q), failure to protect a resident from undue medication consequences and/or failure to provide medications as prescribed leads to a finding of immediate jeopardy.

The OBRA regulations did succeed in reducing the use of inappropriate antipsychotic medications in nursing facilities. There is also some evidence to suggest that errors in dispensing and administration of medications are lower in long-term care facilities than in hospitals. But there is no evidence to date that the regulations had any impact on reduction of medications errors related to prescribing and monitoring.

Realizing that regulations are not an appropriate way to improve care, and responding to members' needs, AMDA formed the Multidisciplinary Medication Management workgroup in collaboration with the American Society of Consultant Pharmacists (ASCP). The goal of Multidisciplinary Medication Management is to develop strategies to help physicians and other care team members in LTC to improve medication management. These strategies include information, education, and development of tools for improvement.

Strategies for Improvement

Physicians are key in making progress towards reducing medication errors; therefore, physicians must be open to education and other interventions that would lead to change in clinical practice. In addition, medical directors are responsible for ensuring that there are processes in place for assessment of residents by attending physicians. Standardized assessment tools such as the Mini-Mental Status exam, Geriatric Depression Scale, and pain assessments, for example, are important for obtaining accurate information about the resident's physical, mental and functional status.

By the same token, physicians need to have knowledge of information related to objective and timely drug information, geriatric practice and pharmacological principles, federal and local regulations, drug costs, and use of information technology to obtain patient and drug data at the point of prescribing.To ensure patient safety, physicians should document the risk-benefit ratio for drugs with a high ADR potential, and consultant pharmacists should focus on these drugs and notify physicians in a timely way, particularly with new prescriptions.

Nursing assessment skills are also critical. They need to be aware of the common geriatric syndromes associated with an adverse drug event and notify the physician when one occurs.

It is also important to note that ADRs may mimic common geriatric syndromes. Thus, practitioners need to avoid the pitfall of mistaking symptoms of ADRs for another condition, inadvertently setting in motion a cascade of treating symptoms with another medication and causing even more ADRs.

Although such strategies are not always easy to implement, the members of the Multidisciplinary Medication Management workgroup are convinced that when applied, these strategies can significantly improve the prescribing and monitoring of medications; cut overuse, underuse, and inappropriate use of medications; and significantly reduce the incidence of medication errors and adverse drug reactions in long-term care. Moreover, the education, information, and process tools gained by physicians in long-term care by these efforts will contribute to the improvement of medical care in all other settings in which long-term care physicians practice.

Study: Adverse Drug Events in Outpatient Elderly Often Preventable

More than a quarter of adverse drug events (ADEs) among older persons in outpatient settings could be considered preventable, according to a study in the March 5 issue of the Journal of the American Medical Association (2003;289:1107-1116).

Jerry H. Gurwitz, MD, of the University of Massachusetts Medical School in Worcester, MA, and colleagues assessed the incidence and preventability of ADEs--defined as an injury resulting from the use of a drug--among 27,617 Medicare enrollees aged 65 and older in an ambulatory clinical setting. The events were categorized as significant, serious, life-threatening or fatal, and may have resulted "from medication errors (i.e., errors in prescribing, dispensing, patient adherence, and monitoring) or from adverse drug reactions in which there was no error. Such events were considered preventable, write the authors, "if they were due to an error and were preventable by any means available."

"There were 1,523 ADEs, of which 27.6% (421) were considered preventable," the authors report. "The overall rate of ADEs was 50.1 per 1,000 person-years, with a rate of 13.8 preventable ADEs per 1,000 person years. Of the adverse drug events, 578 (38%) were categorized as serious, life-threatening, or fatal; 244 (42.2%) of these more severe events were deemed preventable compared with 177 (18.7%) of the 945 significant ADEs. Errors associated with preventable adverse drug events occurred most often at the stages of prescribing (246, or 58.4%) and monitoring (256, or 60.8%), and errors involving patient adherence (89, or 21.1%) also were common," the authors note.

"Prevention strategies should target the prescribing and monitoring stages of pharmaceutical care. Interventions focused on improving patient adherence with prescribed regimens and monitoring of prescribed medications also may be beneficial," the authors conclude.

In an accompanying editorial, David Classen, MD, of the University of Utah, Salt Lake City, observes that "this study builds on a previous study of this group in the inpatient and nursing home settings in which they developed and tested consistent methods for the detection, characterization, and analysis of adverse drug events." Several interventions that are effective in reducing medication errors in the inpatient setting could be generalized to the outpatient setting, he adds, including "computerized physician order entry of medications with decision support (i.e. , drug interaction checking, allergy checking, dose and frequency adjusting, and treatment duration limits), clinical pharmacist consultation services, and clinics for anticoagulation therapy."


This article originally appeared in Caring for the Ages, April 2003; Vol. 4 No. 4, p. 49-51. Caring for the Ages is an official publication of the American Medical Directors Association, published by Elsevier. This article may not be reproduced in any form, print or electronic, without permission.

The opinions expressed by the authors are their own
and not necessarily those of AMDA or of Elsevier.

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